Appendix 01: 12th Report on Carcinogens

Formal Background Documents for a RoC nomination were first prepared for reviews for the 8th RoC that was published in 1998. The following is an alphabetized list of the available Background Documents and public comments for the nominations that have been reviewed for the RoC since 1996. No formal Background Documents for the nominations reviewed prior to 1996 are available.

A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z

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A

• Alcoholic Beverage Consumption
  • Summary of Information
  • Background Document(3.5 mb)
    • Appendix A contained in background document
    • Appendix B: IARC Monographs on the Evaluation of the Carcinogenic Risk to Humans: Alcohol Drinking (Volume 44), 1988
    • Appendix C contained in background document
  • Public Comments
  • Summary of Committee Reviews
• 1-Amino-2,4,dibromoanthraquinone (ADBAQ)
  • Summary of Information
  • Background Document(5.3 mb)
    • Appendix A: NTP TR 383 (1996). Toxicology and Carcinogenesis Studies of 1-mino-2.4-Dibromoanthraquinone inF344/N Rats and B6C3F1 Mice (Feed Studies). PP A-1 – A-86(333 kb)
    • Appendix B contained in background document
    • Public Comments
    • RG1 Review Summary Document for ADBAQ(88.5 kb)
    • RG2 Review Summary Document for ADBAQ(29.4 kb)
    • NTP BSC RoC Subcommittee Meeting Minutes  (538 kb)
  • 2-Amino-3,4-dimethylimidazo[4-5-f]quinoline (MeIQ)
    • See Heterocyclic Amines (Selected)
  • 2-Amino-3,8-dimethylimidazo[4-5-f]quinoxaline (MeIQx)
    • See Heterocyclic Amines (Selected)
  • 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)
    • See Heterocyclic Amines (Selected)
  • 2-Amino-3-methylimidazo[4,5-f]quinoline (IQ)
    • Summary of Information
    • Background Document(360 kb)
      • Appendix A: IARC. (1993). Some Naturally Occurring Substances: Food Items and Constituents, Heterocyclic Aromatic Amines, and Mycotoxins. Monographs of Evaluation of Carcinogenic Risks to Humans. IQ (2-Amino-3-methylimidazo[4,5-f]quinoline). Lyon, France. World Health Organization. Volume 56 pp. 166-195. 
    • No Public Comments
    • Summary of Committee Reviews
  • Aristolochic Acids
    • Summary of Information
    • Final Background Document(2.0 mb)
      • Appendix A contained in background document
      • Appendix B contained in background document
      • Appendix C contained in background document
    • Public Comments
      • NTP Response to Public Comments  (429 kb)
    • Expert Panel Meeting
    • NTP Board of Scientific Counselors Meeting (February 24, 2009)
  • Azacitidine
    • Summary of Information
    • Background Document(3.0 mb)
      • Appendix A contained in background document
      • Appendix B contained in background document
    • No Public Comments
    • Summary of Committee Reviews
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B

• • Beryllium and Beryllium Compounds
    • Summary of Information
    • Background Document(1.4 mb)
      • Appendix A: IARC. 1993. Beryllium, Cadmium, Mercury and Exposures in the Glass Manufacturing Industry. Monographs on the Evaluation of Carcinogenic Risks to Humans. Beryllium and Beryllium Compounds. World Health Organization. Lyon, France. Vol. 58, pp. A-1 – A-77 
      • Appendix B contained in background document
      • Appendix C contained in background document
    • Public Comments
    • Summary of Committee Reviews
  • 2,2-bis-(bromomethyl)-1,3-propanediol (BBMP) (Technical Grade)
    • Summary of Information
    • Background Document(1.5 mb)
      • Appendix A: NTP (1996). Technical Report on the Toxicology and Carcinogenesis Studies of 2,2-bis(bromomethyl)-1,3-propanediol in Rats and B6C3F1 Mice, NTP TR 452, pp 5 – 102  (16.2 mb)
      • Appendix B contained in background document
    • No Public Comments
    • Summary of Committee Reviews
  • Boot & Shoe Manufacturing
    • Summary of Information
    • Background Document(3.5 mb)
      • Appendix A contained in background document
      • Appendix B contained in background document
      • Appendix C contained in background document
      • Appendix D contained in background document
    • Public Comments
    • Summary of Committee Reviews
  • 1,3- Butadiene
    • Summary of Information
    • Background Document(8.1 mb)
      • Appendix A contained in background document
      • Appendix B contained in background document
      • Appendix C contained in background document
      • Appendix D contained in background document
    • Public Comments
    • Summary of Committee Reviews
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C

• • Cadmium and Cadmium Compounds
    • Summary of Information
    • Background Document(12.0 mb)
      • Appendix A contained in background document
      • Appendix B contained in background document
      • Appendix C contained in background document
      • Appendix D contained in background document
    • Public Comments
    • Summary of Committee Reviews
  • Captafol
    • Summary of Information
    • Final Background Document(647.0 kb)
    • Public Comments
      • NTP Response to Public Comments  (429 kb)
    • Expert Panel Meeting
    • NTP Board of Scientific Counselors Meeting (February 24, 2009)
  • Ceramic Fibers (Respirable Size)
    • Public Comments
  • Chloramphenicol
    • Summary of Information
    • Background Document(303.0 kb)
      • Appendix A: IARC (1990). Pharmaceutical Drugs. Monographs on the Evaluation of Carcinogenic Risks to Humans. World Health Organization. Lyon, France. Vol. 50. PP A-1 - A-26.
    • Public Comments
    • Summary of Committee Reviews
  • Chloroprene
    • Summary of Information
    • Background Document(5.5 mb)
      • Appendix A contained in background document
      • Appendix B contained in background document
      • Appendix C contained in background document
      • Appendix D contained in background document
      • Appendix E contained in background document
      • Appendix F contained in background document
    • Public Comments
    • Summary of Committee Reviews
  • Chlorozotocin (CZT)
    • Summary of Information
    • Background Document(1.3 mb)
      • Appendix A contained in background document
      • Appendix B contained in background document
    • No Public Comments
    • Summary of Committee Reviews
  • p-Chloro-o-toluidine and its Hydrochloride Salt
    • Summary of Information
    • Background Document(2.3 mb)
      • Appendix A contained in background document
      • Appendix B contained in background document
    • No Public Comments
    • Summary of Committee Reviews
  • Cobalt Sulfate
    • Summary of Information
    • Background Document(376 kb)
      • Appendix A:  IARC (1991). Monographs on the Evaluation of Carcinogenic Risks to Humans. Chlorinated Drinking-Water: Chlorination By-products; Some Other Halogenated Compounds: Cobalt and Cobalt Compounds. V 52. pp 363 - 472.
      • Appendix B:  NTP (1998). Toxicology and Carcinogenesis Studies of Cobalt Sulfate Heptahydrate in F344/N Rats and B6C3F1 Mice (Inhalation Studies). TR No. 471. pp 5 - 62.
    • Public Comments
    • RG1 Review Summary Document for Cobalt Sulfate(91.6 kb)
    • RG2 Review Summary Document for Cobalt Sulfate(94.1 kb)
    • Cobalt Sulfate Commentary (RG2)(181.0 kb)
    • NTP BSC RoC Subcommittee Meeting Minutes  (563.8 kb)
  • Cobalt-Tungsten Carbide Powders and Hard Metals
    • Summary of Information
    • Final Background Document(2.4 Mb)
      • Appendix A contained in background document
      • Appendix B contained in background document
    • Public Comments
      • NTP Response to Public Comments  (429 kb)
    • Expert Panel Meeting
    • NTP Board of Scientific Counselors Meeting (June 21-22, 2010)
  • Cyclosporin A
    • Summary of Information
    • Background Document(4.2 mb)
      • Appendix A contained in background document
      • Appendix B contained in background document
    • No Public Comments
    • Summary of Committee Reviews
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D

• • Danthron (1,8-Dihydroxyanthraquinone)
    • Summary of Information
    • Background Document(1.8 mb)
      • Appendix A contained in background document
      • Appendix B contained in background document
    • No Public Comments
    • Summary of Committee Reviews
  • Diazoaminobenzene (DAAB)
    • Summary of Information
    • Background Document(459 kb)
      • Appendix A: NTP TR 73 (2002). NTP Report on the Metabolism, Toxicity, and Predicted Carcinogenicity of Diazoaminobenzene (CAS No 136-35-6). pp 1 - B24.(2.5 mb)
    • No Public Comments
    • RG1 Review Summary Document for Diazoaminobenzene (DAAB)(65.0 kb)
    • RG2 Review Summary Document for Diazoaminobenzene (DAAB)(78.0 kb)
    • NTP BSC RoC Subcommittee Meeting Minutes(1.8 mb)
  • 2,3-Dibromo-1-propanol (DBP)
    • Background Document(360 kb)
      • Appendix A: Technical Report on the Toxicology and Carcinogenesis Studies of 2,3-Dibromo-1-propanol in F344/N Rats and B6C3F1 Mice (Dermal Studies), NTP TR 400. NTP. (1993). (10.2 Mb).
      • Appendix B: Some Halogenated Hydrocarbons. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. Tris(2,37 Dibromopropyl) Phosphate. Vol 20. IARC. (1979).
    • Summary of Information
    • No Public Comments
    • Summary of Committee Reviews
  • Diesel Exhaust Particulates
    • Summary of Information
    • Background Document(2.5 mb)
      • Appendix A-1 contained in background document
      • Appendix A-2 contained in background document
      • Appendix A-3 contained in background document
    • Public Comments
    • Summary of Committee Reviews
  • Diethanolamine (DEA)
    • Summary of Information
    • Background Document(430 kb)
      • Appendix A: IARC (2000). Monographs on the Evaluation of Carcinogenic Risks to Humans. Some Industrial Chemicals. V. 77. pp 349 - 379.
      • Appendix B: NTP (1999). Toxicology and Carcinogenesis Studies of Diethanolamine in F344/N Rats and B6C3F1 Mice (Dermal Studies). TR 478. pp 5 - 60.(4.7 mb)
      • Appendix C: NTP (1992). NTP Technical Report on Toxicity Studies of Diethanolamine (CAS No. 111-42-2) Administered Topically and in Drinking Water to F344/N Rats and B6C3F1 Mice. TOX 20. pp 7 - 53 and D1 - D9.  (2.1 mb)
    • Public Comments
    • RG1 Review Summary Document for Diethanolamine(72.8 kb)
    • RG2 Review Summary Document for Diethanolamine(81.7 kb)
    • NTP BSC RoC Subcommittee Meeting Minutes  (563.8 kb)
  • 1,6-Dinitropyrene & 1,8-Dinitropyrene
    • Summary of Information
    • Background Document(3.5 mb)
      • Appendix A contained in background document
      • Appendix B contained in background document
    • No Public Comments
    • Summary of Committee Reviews
  • Disperse Blue I
    • Summary of Information
    • Background Document(1.8 mb)
      • Appendix A contained in background document
      • Appendix B contained in background document
    • No Public Comments
    • Summary of Committee Reviews
  • Dyes Metabolized to Benzidine (Benzidine Dyes as a Class)
    • Summary of Information
    • Background Document(7.8 mb)
      • Appendix A contained in background document
      • Appendix B contained in background document
      • Appendix C contained in background document
      • Appendix D contained in background document
      • Appendix E contained in background document
      • Appendix F contained in background document
      • Appendix G contained in background document
      • Appendix H contained in background document
    • No Public Comments
    • Summary of Committee Reviews
  • Dyes metabolized to 3,3'-Dimethoxybenzidine (DMOB)
    • Summary of Information
    • Background Document(925 kb)
      • Appendix A: IARC. 1974. Some Aromatic Amines, Hydrazine and Related Substances, N-Nitroso Compounds and Miscellaneous alkylating Agents. 3,3';-Dimethoxybenzidine. IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Man. Lyon, France. World Health Organization. Vol. 4. A-1 – A-10.
      • Appendix B: IARC. 1993. Occupational Exposures of Hairdressers and Barbers and Personal Use of Hair Colourants; Some Hair Dyes, Cosmetic Colourants, Industrial Dyestuffs and Aromatic Amines. C.I. Direct Blue 15. IARC Monographs on the Evaluation of the Carcinogenic Risk to Humans. Lyon, France. World Health Organization. Vol. 57. Pp. B-1 – B-14.
      • Appendix C contained in background document
      • Appendix D: NTP. 1990. Toxicology and Carcinogenesis Studies of DMOB Dihydrochloride in F344/N rats (Drinking Water Studies). NTP Technical Report Series TR-372. Pp. D-1 – D-68.  (10.1 mb kb)
      • Appendix E: NTP. 1992. Toxicology and Carcinogenesis Studies of C.I. Direct Blue 15 in F344/N rats. NTP Technical Report Series TR-397. pp. E-1 – E-76.  (11.1 mb)
      • Appendix F contained in background document
    • Public Comments
    • Summary of Committee Reviews
  • Dyes metabolized to 3,3'-Dimethylbenzidine (DMB)
    • Summary of Information
    • Background Document(426 kb)
      • Appendix A: IARC. (1972). Some Inorganic Substances, Chlorinated Hydrocarbons, Aromatic Amines, N-Nitroso Compounds, and Natural Products. Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Humans. 3,3'-Dimethylbenzidine (o-Tolidine). Lyon, France. World Health Organization. Vol 1, pp. A-1 – A-8.
      • Appendix B: IARC. (1993). Occupational Exposures of Hairdressers and Barbers and Personal Use of Hair Colourants; Some Hair Dyes, Cosmetic Colourants, Industrial Dyestuffs and Aromatic Amines. Monographs on the Evaluation of the Carcinogenic Risk to Humans. C.I. Acid Red 114. Lyon, France. World Health Organization. Vol 57, pp. B-1 - B-12.
      • Appendix C: NTP. (1991). Toxicology and Carcinogenesis Studies of C.I. Acid Red 114 (CAS No. 6459-94-5) in F344/N Rats (Drinking Water Studies). National Toxicology Program Technical Report Series No. 405. pp. C-1 –C-68.  (9.8 mb kb)
      • Appendix D: NTP. (1991). Toxicology and Carcinogenesis Studies of 3,3'-Dimethylbenzidine Dihydrochloride in F344/N Rats (Drinking Water Studies). National Toxicology Program Technical Report Series No. 390. pp. D-1 –D-74.  (10.2 mb kb)
      • Appendix E contained in background document
    • Public Comments
    • Summary of Committee Reviews
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E

• • Environmental Tobacco Smoke
    • Summary of Information
    • Background Document(1.9 mb)
      • Appendix 1: contained in background document
      • Appendix 2: contained in background document
      • Appendix 3A: IARC (1986) Vol. 38. Evaluation of the carcinogenic risk of chemicals to humans – Tobacco Smoking Epidemiology Studies of Cancer in Humans pp. 199-375.
      • Appendix 3B: U.S.EPA (1992) Respiratory health effects of passive smoking: lung cancer and other disorders. EPA/600/6-90/006F Chapter 5: Hazard Identification II: Interpretation of Epidemiologic Studies on Environmental Tobacco Smoke and Lung Cancer Appendix A Table 4-10 Study scores for tier assignments
      • Appendix 3C: California EPA (1997) Health Effects of Exposure of Environmental Tobacco Smoke. Chapter 7: Carcinogenic Effects
    • Public Comments
    • Summary of Committee Reviews
  • Estrogens, Steroidal
    • Summary of Information
    • Background Document(685 kb)
      • Appendix A: IARC Monographs on the Evaluation of the Carcinogenic Risks to Humans. Hormonal Contraception and Post-menopausal Hormonal Therapy. V 72. 1999pp 288-294, 498-500, 556-558. 
      • Appendix B: IARC Monographs on the Evaluation of the Carcinogenic Risks to Humans. Overall Evaluation of Carcinogenicity: An Updating of IARC Monographs.Suppl. 7. 1987. 
      • Appendix C: IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. Sex Hormones (II). Vol 21. 1979 pp 62-82, 155-159, 242-255, 264-278, 298-326, 335-341, 352-362. 
      • Appendix D contained in background document
    • Public Comments
    • Summary of Committee Reviews
  • Ethyl Acrylate
    • Summary of Information
    • Background Document(589 kb)
      • Appendix A: IARC Monographs. 1986. Vol 39: 81-98. Some chemicals used in plastics and elastomers. IARC evaluation of the carcinogenic risk of chemicals to humans.
    • Public Comments
    • Summary of Committee Reviews
  • Ethylene Oxide
    • Summary of Information
    • Background Document(3.7 mb)
      • Appendix A: Excerpts from the IARC Monograph on the Evaluation of the Carcinogenic Risk of Chemicals to Humans Volume 60 (Some Industrial Chemicals) Ethylene Oxide pp. 73-159, 1994.   
      • Appendix B contained in background document
    • Public Comments
    • Summary of Committee Reviews
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F

• • Formaldehyde
    • Summary of Information
    • Final Background Document(3.6 mb)
    • Public Comments
      • NTP Response to Public Comments  (429 kb)
    • Expert Panel Meeting
    • NTP Board of Scientific Counselors Meeting (June 21-22, 2010)
  • Furan
    • Summary of Information
    • Background Document(2.8 mb)
      • Appendix A contained in background document
      • Appendix B contained in background document
    • No Public Comments
    • Summary of Committee Reviews
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G

• • Gamma Radiation
    • See X-Radiation & Gamma Radiation and Neutrons
  • Certain glass wool fibers (inhalable)
    • Summary of Information
    • Final Background Document  (2.2 Mb)
    • Public Comments
      • NTP Response to Public Comments  (429 kb)
    • Expert Panel Meeting
    • NTP Board of Scientific Counselors Meeting (June 21-22, 2010)
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H

• • Hepatitis B Virus (HBV)
    • Summary of Information
    • Background Document(1.7 mb)
    • No Public Comments
    • RG1 Review Summary Document for Hepatitis B Virus (HBV)(65.7 kb)
    • RG2 Review Summary Document for Hepatitis B Virus (HBV)(78.2 kb)
    • NTP BSC RoC Subcommittee Meeting Minutes  (1.8 mb)
  • Hepatitis C Virus (HCV)
    • Summary of Information
    • Background Document(1.1 mb)
    • No Public Comments
    • RG1 Review Summary Document for Hepatitis C Virus (HCV)(50.3 kb)
    • RG2 Review Summary Document for Hepatitis C Virus (HCV)(73.2 kb)
    • NTP BSC RoC Subcommittee Meeting Minutes  (1.8 mb)
  • Heterocyclic Amines (Selected): PhIP, MeIQ, and MeIQx
    • Summary of Information
    • Background Document(886.5 kb)
    • Public Comments
      • 2-Amino-3,4-dimethylimidazo[4,5-f]quinoline (MeIQ)
      • 2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx)
      • 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)
    • RG1 Review Summary Document for Selected Heterocyclic Amines (HCAs)(185.6 kb)
    • RG2 Review Summary Document for Selected Heterocyclic Amines (HCAs)(31.3 kb)
    • NTP BSC RoC Subcommittee Meeting Minutes  (538 kb)
  • Human Papillomaviruses (HPV): Some Genital-Mucosal Types
    • Summary of Information
    • Background Document(1.1 mb)
    • Public Comments
    • RG1 Review Summary Document for Human Papillomaviruses: Genital-Mucosal Types(54.0 kb)
    • RG2 Review Summary Document for Human Papillomaviruses: Genital-Mucosal Types(76.6 kb)
    • NTP BSC RoC Subcommittee Meeting Minutes  (1.8 mb)
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I

• • Isoprene
    • Summary of Information
    • Background Document(2.0 mb)
      • APPENDIX A: Excerpt from IARC Monograph (1994) Volume 60; pp. 215-232 
      • Appendix B contained in background document
    • Public Comments
    • Summary of Committee Reviews
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L

• • Lead and Lead Compounds
    • Summary of Information
    • Background Document(1.4 mb)
      • Appendix A contained in background document
    • Public Comments
    • RG1 Review Summary Document for Lead and Lead Compounds(75.4 kb)
    • RG2 Review Summary Document for Lead and Lead Compounds(78.0 kb)
    • NTP BSC RoC Subcommittee Meeting Minutes  (1.8 mb)
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M

• • Methyleugenol
    • Summary of Information
    • Background Document(785 kb)
      • Appendix A: NTP (2000). Technical Report on the Toxicology and Carcinogenesis Studies of Methyleugenol in F344/N Rats and B6C3F1 Mice (Gavage Studies), NTP TR. 491. pp 1-97.  (16.4 mb)
    • Public Comments
    • Summary of Committee Reviews
  • Methyl-t-Butyl Ether (MtBE)
    • Summary of Information
    • Background Document(650.0 kb)
    • Public Comments
    • Summary of Committee Reviews
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N

• • Naphthalene
    • Summary of Information
    • Background Document(864 kb)
      • Appendix A: NTP (1992). Toxicology and Carcinogenesis Studies of Naphthalene (CAS No. 91-20-3) in B6C3F1 Mice (Inhalation Studies). TR 410. PP A-1 – A-173.  (7.9 mb)
      • Appendix B: NTP (2000). Toxicology and Carcinogenesis Studies of Naphthalene (CAS No. 91-20-3) in F344/N Rats (Inhalation Studies). TR 500. PP B-1 – B-177.  (5.1 mb)
    • Public Comments
    • RG1 Review Summary Document for Naphthalene(88.7 kb)
    • RG2 Review Summary Document for Naphthalene(32.5 kb)
    • NTP BSC RoC Subcommittee Meeting Minutes  (538 kb)
  • Neutrons
    • See X-Radiation & Gamma Radiation and Neutrons
  • Nickel Compounds
    • Summary of Information
    • Background Document(4.6 mb)
      • Appendix A: Excerpts from the IARC Monograph on the Evaluation of the Carcinogenic Risks to Humans Volume 49 Chromium, Nickel and Welding) Nickel and Nickel Compounds pp.257-445,616-638,1990 
      • Appendix B contained in the background document
    • Public Comments
    • Summary of Committee Reviews
  • Nickel (Metallic) and Certain Nickel Alloys
    • Summary of Information
    • Background Document(625 kb)
      • Appendix A: IARC. (1990). Chromium, Nickel, and Welding. Monographs on the Evaluation of Carcinogenic Risks to Humans. Nickel. World Health Organization. Lyon, France. Vol. 49. PP. 257-445. 
      • Appendix B: IARC. (1990). Chromium, Nickel, and Welding. Monographs on the Evaluation of Carcinogenic Risks to Humans. Nickel (Tables for Genotoxicity). World Health Organization. Lyon, France. Vol. 49. PP. B-1 – B-9 
      • Appendix C: IARC. (1999). Surgical Implants and Other Foreign Bodies. Monographs on the Evaluation of Carcinogenic Risks to Humans. World Health Organization. Lyon, France. Vol. 74. PP. C-1 – C-125. 
      • Appendix D contained in background document
    • Public Comments
    • Summary of Committee Reviews
  • o-Nitroanisole
    • Summary of Information
    • Background Document(2.1 mb)
      • Appendix A contained in background document
      • Appendix B contained in background document
      • Appendix C contained in background document
    • No Public Comments
    • Summary of Committee Reviews
  • Nitrobenzene
    • Summary of Information
    • Background Document(463 kb)
      • Appendix A: IARC (1996). Monographs on the Evaluation of Carcinogenic Risks to Humans. Nitrobenzene. In Printing Processes, Printing Inks, Carbon Blacks and Some Nitro Compounds. V 65. pp 381 - 408. 
      • Appendix B contained in background document
    • Public Comments
    • RG1 Review Summary Document for Nitrobenzene(89.8 kb)
    • RG2 Review Summary Document for Nitrobenzene(29.4 kb)
    • NTP BSC RoC Subcommittee Meeting Minutes  (538 kb)
  • 6-Nitrochrysene
    • Summary of Information
    • Background Document(2.5 mb)
      • Appendix A contained in background document
      • Appendix B contained in background document
    • No Public Comments
    • Summary of Committee Reviews
  • Nitromethane
    • Summary of Information
    • Background Document(332 kb)
      • Appendix A: IARC (2000). Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. Nitromethane. In Some Industrial Chemicals. V 77. PP A-1 – A-15 
      • Appendix B: NTP (1997). Toxicology and Carcinogenesis Studies of Nitromethane (CAS No. 75-52-5) in F344/N Rats and B6C3F1 Mice (Inhalation Studies). TR 461. PP B-1 – B-63(15 mb)
    • Public Comments
    • RG1 Review Summary Document for Nitromethane(97.9 kb)
    • RG2 Review Summary Document for Nitromethane(92.8 kb)
    • NTP BSC RoC Subcommittee Meeting Minutes  (538 kb)
  • 1-Nitropyrene
    • Summary of Information
    • Background Document(3.5 mb)
      • Appendix A contained in background document
      • Appendix B contained in background document
    • No Public Comments
    • Summary of Committee Reviews
  • 4-Nitropyrene
    • Summary of Information
    • Background Document(1.2 mb)
      • Appendix A contained in background document
      • Appendix B contained in background document
    • No Public Comments
    • Summary of Committee Reviews
  • ortho-Nitrotoluene
    • Summary of Information
    • Final Background Document(1.1 mb)
    • Public Comments
      • NTP Response to Public Comments  (429 kb)
    • Expert Panel Meeting
    • NTP Board of Scientific Counselors Meeting (February 24, 2009)
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P

• • Phenolphthalein
    • Summary of Information
    • Background Document(1.9 mb)
      • Appendix A: Excerpt from the NTP Technical Report Toxicology and Carcinogenesis Studies of Phenolphthalein in F344/N Rats and B6C3F1 Mice (Feed Studies), TR-465, pp. 4-38, 71-91, November 1996.  (14 mb)
      • Appendix B contained in background document
      • Appendix C contained in background document
    • Public Comments
    • Summary of Committee Reviews
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R

• • Riddelliine
    • Summary of Information
    • Final Background Document(1.4 mb)
    • No Public Comments
    • Expert Panel Meeting
    • NTP Board of Scientific Counselors Meeting (February 24, 2009)
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S

• • Saccharin
    • Summary of Information
    • Background Document(7.9 mb)
      • Appendix A: Excerpts from the IARC Monograph on the Evaluation of the Carcinogenic Risk of Chemicals to Humans Volume 22 (Some Non-Nutritive Sweetening Agents) Saccharin, pp. 111-185, 1980 
      • Appendix B: Excerpts from the IARC Monograph on the Evaluation of the Carcinogenic Risk of Chemicals to Humans Supplement 4 (Chemicals, Industrial Processes and Industries Associated with Cancer in Humans, IARC Monographs Volumes 1 to 9) Saccharin pp. 224-226, 1982 
      • Appendix C: Excerpts from the IARC Monograph on the Evaluation of the Carcinogenic Risk of Chemicals to Humans Supplement 7 (Overall Evaluations of Carcinogenicity: An updating of IARC Monographs Volumes 1 to 42) Saccharin pp. 334-339, 1987 
      • Appendix D contained in background document
      • Appendix E contained in background document
      • Appendix F contained in background document
    • Public Comments
    • Summary of Committee Reviews
  • Silica, Crystalline (Respirable Size)
    • Summary of Information
    • Background Document(1.1 mb)
      • Appendix A: IARC Monographs.1997. Vol 68:41-242. 
    • Public Comments
    • Summary of Committee Reviews
  • Smokeless Tobacco
    • Summary of Information
    • Background Document(2.0 mb)
      • Appendix A: Excerpts from the IARC Monograph on the Evaluation of the Carcinogenic Risks of Chemicals to Humans Volume 37 (Tobacco Habits Other Than Smoking) 1985, pp. 37-136 
      • Appendix B contained in background document
      • Appendix C contained in background document
    • Public Comments
    • Summary of Committee Reviews
  • Solar Radiation & Exposure to Sunlamps or Sunbeds
    • Summary of Information
    • Background Document(2.5 mb)
      • Appendix A: Excerpts from the IARC Monograph on the Evaluation of the Carcinogenic Risk of Chemicals to Humans Volume 55 (Solar and Ultraviolet Radiation) pp. 43-290, 1992 
      • Appendix B contained in background document
      • Appendix C contained in background document
    • Public Comments
    • Summary of Committee Reviews
  • Strong Inorganic Acid Mists Containing Sulfuric Acid
    • Summary of Information
    • Background Document(1.4 mb)
      • Appendix A: Excerpts from the IARC Monograph on the Evaluation of the Carcinogenic Risk of Chemicals to Humans, Volume 54 (Occupational Exposures to Mist and Vapors from Strong Inorganic Acids; and Other Industrial Chemicals), 1992, Sulfuric Acid and Other Strong Inorganic Acids, pp. 41-130 
      • Appendix B contained in background document
      • Appendix C contained in background document
    • Public Comments
    • Summary of Committee Reviews
  • Styrene
    • Summary of Information
    • Final Backgound Document(2.5 mb) Erratum and Addendum  (99 kb)
    • Public Comments
      • NTP Response to Public Comments  (429 kb)
    • Expert Panel Meeting
    • NTP Board of Scientific Counselors Meeting (February 24, 2009)
  • Styrene-7,8-oxide
    • Summary of Information
    • Background Document(201 kb)
      • Appendix A: IARC. 1976. Cadmium, Nickel, Some Epoxides, Miscellaneous Industrial Chemicals and General Considerations on Volatile Anaesthetics. Styrene oxide. IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Man. Lyon, France. World Health Organization. Vol 11, (A-1 – A-10) 
      • Appendix B: IARC. (1979). Some Monomers, Plastics, and Synthetic Elastomers, and Acrolein. Styrene oxide. IARC Monographs on the Evaluations of the Carcinogenic Risk of Chemicals to Humans. Lyon, France. World Health Organization. Vol 19, B-1 – B-12. 
      • Appendix C: IARC. (1985). Allyl Compounds, Aldehydes, Epoxides and Peroxides. Styrene Oxide. IARC Monographs on the Carcinogenic Risks of Chemicals to Humans. Lyon, France. World Health Organization. Vol 36, C-1 – C-22. 
      • Appendix D: IARC. (1994a). Some Industrial Chemicals. Styrene-7,8-oxide. IARC Monographs on the Carcinogenic Risks to Humans. Lyon, France. World Health Organization. Vol 60, D-1 – D-28. 
      • Appendix E: Phillips, D.H. and P.B. Farmer. (1994). Evidence for DNA and protein binding by styrene and styrene oxide. Crit Rev Toxicol. 24(S1):S35-S46. Pp. E-1 – E-12.
    • Public Comments
    • Summary of Committee Reviews
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T

• • Tamoxifen
    • Summary of Information
    • Background Document(1.6 mb)
      • Appendix A: Excerpts from the IARC Monograph on the Evaluation of the Carcinogenic Risks of Chemicals to Humans Volume 66 (Some Pharmaceutical Drugs) Tamoxifen, pp. 253-365, 1996 
      • Appendix B contained in background document
      • Appendix C contained in background document
    • Public Comments
    • Summary of Committee Reviews
  • 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)
    • Summary of Information
    • Background Document(3.1 mb)
      • Appendix A: Excerpts from the IARC Monograph on the Evaluation of the Carcinogenic Risk of Chemicals to Humans Volume 69 (Polychlorinated Dibenzo-para-Dioxins and Polychlorinated Dibenzofurans) 2,3, 7,8-TCDD pp. 3-343, 525-630, 1997 
      • Appendix B contained in background document
      • Appendix C contained in background document
      • Appendix D contained in background document
      • Appendix E contained in background document
    • Public Comments
    • Summary of Committee Reviews
  • Tetrafluoroethylene
    • Summary of Information
    • Background Document(1.0 mb)
      • Appendix A: Excerpts from the IARC Monograph on the Evaluation of the Carcinogenic Risk of Chemicals to Humans Volume 19 (Some Monomers, Plastics and Synthetic Elastomers, and Acrolein) Tetrafluoroethylene and Polytetrafluoroethylene pp. 285-301, 1979 
      • Appendix B: Excerpts from the NTP Technical Report Toxicology and Carcinogenesis Studies of Tetraftuoroethylene in F344/N Rats and B6C3Fl Mice (Inhalation Studies) April1997, pp. 3-32, 69-78 (1.9 mb)
      • Appendix C contained in background document
      • Appendix D contained in background document
    • Public Comments
    • Summary of Committee Reviews
  • 4,4'-Thiodianiline
    • Summary of Information
    • Background Document(1.1 mb)
      • Appendix A: IARC (1982). Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. Some Aromatic Amines, Anthraquinones and Nitroso Compounds, and Inorganic Fluorides Used in Drinking Water and Dental Preparations. V 27. pp 147-154. 
      • Appendix B: NCI TR 47 (1978). Bioassay of 4,4'-Thiodianiline for Possible Carcinogenicity. DHEWPublication No. 78-847. pp vii - 106.(2.7 mb)
    • Public Comments
    • RG1 Review Summary Document for 4,4'-Thiodianiline(98.2 kb)
    • RG2 Review Summary Document for 4,4'-Thiodianiline(94.5 kb)
    • NTP BSC RoC Subcommittee Meeting Minutes  (538 kb)
  • Thiotepa
    • Summary of Information
    • Background Document(1.9 mb)
      • Appendix A contained in background document
      • Appendix B contained in background document
    • No Public Comments
    • Summary of Committee Reviews
  • Tobacco Smoking
    • Summary of Information
    • Background Document(1.9 mb)
      • Appendix A: Excerpts from the IARC Monograph on the Evaluation of the Carcinogenic Risk of Chemicals to Humans Volume 38 (Tobacco Smoking) 1986 pp. 15-34, 47-81, 86-87, 127-375 
      • Appendix B: Excerpts from the NCI Monograph on Smoking and Tobacco Control (Changes in Cigarette-Related Disease and their Implication for Prevention and Control) Monograph 8, 1997, pp. 1-11
      • Appendix C contained in background document
      • Appendix D contained in background document
    • Public Comments
    • Summary of Committee Reviews
  • 1,2,3-Trichloropropane
    • Summary of Information
    • Background Document(2.4 mb)
      • Appendix A contained in background document
      • Appendix B contained in background document
    • No Public Comments
    • Summary of Committee Reviews
  • Trichloroethylene (TCE)
    • Summary of Information
    • Background Documents
      • 1997 Review(1.1 mb)
        • Appendix A: Eexcerpts from the IARC Monograph on the Evaluation of the Carcinogenic Risk of Chemicals to Humans Volume 63 (Dry Cleaning, Some Chlorinated Solvents and Other Industrial Chemicals) Trichloroethylene pp. 75-158 (1995) 
        • Appendix B: Excerpts from the 1990 NTP Technical Report Toxicology and Carcinogenesis Studies ofTrichloroethylene (Without Epichlorohydrin) [CAS No. 79-01-6] in F344/N Rats and B6C3F1 Mice (Gavage Studies) pp. 7-8, 34-39, 46-51(6 mb)
        • Appendix C contained in background document
        • Appendix D contained in background document
      • 2000 Review(544 kb)
        • Appendix A: Eexcerpts from the IARC Monograph on the Evaluation of the Carcinogenic Risk of Chemicals to Humans Volume 63 (Dry Cleaning, Some Chlorinated Solvents and Other Industrial Chemicals) Trichloroethylene pp. 75-158 (1995) 
        • Appendix B: Excerpts from the 1990 National Toxicology Program (NTP) Technical Report Toxicology and Carcinogenesis Studies of Trichloroethylene (Without Epichlorohydrin) [CAS No. 79-01-6] in F344/N Rats and B6C3F1 Mice (Gavage Studies) (TR-243) pp. 16-60(6 mb)
        • Appendix C contained in background document
    • Public Comments
      • 1997 Review
      • 2000 Review
    • Summary of Committee Reviews
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U

• • Ultraviolet (UV) Radiation, Broad Spectrum and UVA, UVB, and UVC
    • Summary of Information
    • Background Document(948 kb)
      • Appendix A: IARC Monograph of Evaluation of Carcinogenic Risks to Humans. Solar and Ultraviolet Radiation. Vol. 55. Lyon, France. World Health Organization. 1992. pp. 43-279. 
      • Appendix B contained in background document
    • Public Comments
    • Summary of Committee Reviews
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V

• • Vinyl Bromide
    • Summary of Information
    • Background Document(192 kb)
      • Appendix A: IARC. (1979). Some Monomers, Plastics and Synthetic Elastomers, and Acrolein. (Vinyl Bromide). Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. Vol. 19. Lyon, France. World Health Organization. pp. 367-375.
      • Appendix B: IARC. (1986). Some Chemicals Used in Plastics and Elastomers. Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Humans. Vol 39.Lyon, France. World Health Organization. pp. 133-145.
      • Appendix C: IARC. (1987). Overall Evaluation of Carcinogenicity: An Updating of IARC Monographs. Volumes 1 to 42. Monographs on the Evaluation of the Carcinogenic Risk of Chemical to Humans. Suppl 7. Lyon, France. World Health Organization. p. 73.
      • Appendix D: IARC. (1999). Re-evaluation of Some Organic Chemicals, Hydrazine, and Hydrogen Peroxide. Monographs on the Evaluation of Carcinogenic Risk to Humans. Vol. 71. Lyon, France. World Health Organization. pp. D-1 – D-6.
      • Appendix E: IARC. (1979). Some Monomers, Plastics and Synthetic Elastomers, and Acrolein. (Vinyl Chloride). Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. Vol. 19. Lyon, France. World Health Organization. pp 377-438.
      • Appendix F: IARC. (1987). Overall Evaluations of carcinogenicity: An Updating of the IARC Monographs. Volumes 1 to 42. Monographs on the Evaluation of the Carcinogenicity. Suppl. 7. Lyon, France. World Health Organization. pp. 373-376.
    • No Public Comments
    • Summary of Committee Reviews
  • Vinyl Fluoride
    • Summary of Information
    • Background Document(184 kb)
      • Appendix A: IARC. (1995). Dry cleaning, Some Chlorinated Solvents and Other Industrial Chemicals. Monographs on the Evaluation of the Carcinogenic Risk to Humans. Vol. 63. World Health Organization. Lyon, France. pp. 467-475.
      • Appendix B: IARC. (1986). Some Chemicals Used in Plastics and Elastomers. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans – Some Chemicals used in plastics and elastomers. Vol 39. World Health Organization. Lyon, France. pp. 147 – 154.
    • No Public Comments
    • Summary of Committee Reviews
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W

• • Wood Dust
    • Summary of Information
    • Background Document(428 kb)
      • Appendix A: IARC (1995). Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. Wood Dust and Formaldehyde. V 62. PP A-1 – A-6.
      • Appendix B: IARC (1987) Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. Overall Evaluations of Carcinogenicity: An Updating of IARC Monographs Volumes 1 to 42. Suppl. 7. PP 378 –387.
    • Public Comments
    • Summary of Committee Reviews
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X

• • X-Radiation & Gamma Radiation and Neutrons
    • Summary of Information
    • Background Document(1.4 mb)
      • Appendix A contained in background document
      • Appendix B contained in background document
      • Appendix C contained in background document
      • Appendix D contained in background document
      • Appendix E contained in background document
      • Appendix F contained in background document
    • Public Comments
    • RG1 Review Summary Document for X-Radiation & Gamma Radiation and Neutrons(83.4 kb)
    • RG2 Review Summary Document for X-Radiation & Gamma Radiation and Neutrons(85.4 kb)
    • NTP BSC RoC Subcommittee Meeting Minutes  (1.8 kb)